Rekhol of the tab. kishechnorast. 400 mg No. 8

tablets "Rekhol" are applied at the following indications:

• an intra hepatic cholestasia at adults, including at patients with chronic hepatitis of various etiology and cirrhosis;
• an intra hepatic cholestasia at pregnant women;
• depressive syndromes.

Structure

Active ingredient - ademetionin (one tablet contains 760 mg of an ademetionin of the 1.4-butandisulfonat, 400 mg of an ademetionin are equivalent).

Excipients: microcrystalline cellulose, krospovidon, silicon dioxide colloidal anhydrous, magnesium stearate, methacrylate copolymer (type A), polyethyleneglycol (macrogoal) 6000, titan dioxide (E 171), ferrous oxide yellow (E172), talc.

Contraindication

• hypersensitivity to active ingredient or to any excipient of drug;
• genetic defects influencing a metioninovy cycle and/or cause a homocystinuria and/or a gipergomotsisteinemiya (for example, insufficiency tsistationin - beta synthases, defect of metabolism of B12 vitamin).

Route of administration

Initial therapy

For oral (internal) administration the recommended dose makes 10-25 mg/kg of body weight a day. The initial dose makes 800 mg/days (two tablets), the general daily dose should not exceed 1600 mg (4 tablets). The daily dose of tablets can be divided into 2-3 receptions.

to Apply

inside on 2-4 tablets a day (800-1600 mg/days).

Duration of therapy depends on weight of a course of the disease and is defined by the doctor individually.

should swallow of

Tablet, without chewing. The tablets "Rekhol" are covered with a special cover which is dissolved only in intestines thanks to what ademetionin it is released in a duodenum. And for full therapeutic effect of a tablet it is necessary to apply to the best absorption of active agent between meals.

Patients of advanced age

Clinical trials which were conducted with ademetioniny did not include enough patients of advanced age (that is patients aged from 65 years) in order that it was possible to define whether the difference on treatment at patients of advanced age and young patients is responsible. However from the available clinical experience of differences in treatment responses at patients of advanced age and young patients it is not revealed. Generally selection of a dose for patients of advanced age needs to be carried out carefully, usually since the minimum recommended dose, considering the increased frequency of decrease in hepatic, renal or warm function, existence of the accompanying morbid conditions and use of medicines.

Feature of use

Pregnant

during clinical trials at women who were treated ademetioniny in the III trimester of pregnancy observed no side reactions.

B I and the II trimester of pregnancy the medicament "Rekhol" should be used only after careful assessment by the doctor of a ratio advantage for pregnant woman/risk for a fruit.

during feeding by a breast can only use medicament when the potential advantage for mother exceeds possible risk for the baby.

Safety and efficiency of use of an ademetionin are not established to children by

.

Drivers

some patients during therapy by medicine can have a dizziness. In such cases it is necessary to refrain from control of vehicles or work with other mechanisms before total disappearance of symptoms which can influence speed of response at the specified types of activity.

Overdose

it was Seldom reported about overdose cases ademetioniny. At overdose the doctors have to address to local poison control centers. Generally, observation of the patient and the supporting treatment is recommended.

Side effects

Most often at treatment ademetioniny it was reported about a headache, diarrheas and nausea.

to Store

in original packing at a temperature not above 25 °C, out of children's reach.

Expiration date - 3 years.