Mefenaminovy acid kaps. 250 mg No. 20

Mefenaminovy acid – medicine from group of non-steroidal anti-inflammatory drugs. Active ingredient – mefenaminovy acid, belongs to derivatives of anthranilic acid, the structure of a molecule is similar to salicylic acid. Substance was developed by the pharmaceutical company "Parke, Davis & Company", the first patent for mefenaminovy acid was taken out in 1961. Immunomodulatory properties began to be studied from 1980th years.

Mefenaminovaya acid has different trade the name and also can be included in composition of the combined medicine.

Main therapeutic effects of Mefenaminovy acid on an organism:

• anesthetizing – the central influence on painful sensitivity and also local activity in the inflammation center;
• anti-inflammatory – prevents development of mediators of inflammation and reduces permeability of vascular walls;
• febrifugal – is braked by synthesis of hypothalamic enzymes and prostaglandins, has direct impact on the center of thermal control;
• immunomodulatory – is stimulated by producing interferon and increases functional activity of T lymphocytes.

for use for children of different age:

• in the form of capsules on 250 mg and 500 mg it is recommended to children 12 years are more senior;
• a tablet on 500 mg is applied to patients 5 years are more senior.

Should adhere to the established dosages to avoid undesirable effects which are most often shown from digestive tract.

Special condition at use of Mefenaminovy acid is administration of medicament after a meal and a zapivaniye of tablets milk.

in acute respiratory infections, flu, pain of different intensity and also in inflammatory diseases of the musculoskeletal system.

Mefenaminovaya both for monotherapy, and in a combination with other medicines. Synergism of immunomodulatory effect of Mefenaminovy acid and antiviral medicaments is proved.

till 8 o'clock.

by Clinical trials proved reduction of duration of a course of the disease and decrease in intensity of symptoms in a SARS and flu. Also Mefenaminovaya acid reduces risk of postinfluenzal complications. During observations, serious side effects at observance of recommendations about use are not registered.

For an exception of the menacing symptoms and production of the correct diagnosis needs to consult with the attending physician.

Indication

Acute respiratory viral infections and flu.

Primary dysmenorrhea. Dysfunctional menorrhagias.

Inflammatory diseases of the musculoskeletal system: pseudorheumatism, rheumatism, Bekhterev's disease.

Pain syndrome of low and average intensity: muscular, joint, traumatic, tooth, headache of various etiology, postoperative and postnatal pain.

Contraindication

Hypersensitivity to medicament components. The bronchospasm, a Quincke's edema, rhinitis, bronchial asthma, a small tortoiseshell in the anamnesis which arose later uses of acetylsalicylic acid or other NPVS. Concomitant use of specific TsOG-2 inhibitors. A peptic ulcer of a stomach and duodenum, including in the anamnesis, inflammatory bowel diseases, diseases of bodies of a hemopoiesis, heavy heart failure, heavy abnormal liver functions or kidneys, gastrointestinal bleedings or the perforation caused by intake of non-steroidal anti-inflammatory drugs, treatment of pain after operation of aortocoronary shunting.

to Apply

inside, to take the medicament after a meal.

to Adults and children 12 years are more senior than

to appoint 250-500 mg 3-4 times a day. In case of need the dose can be raised to 3 g a day. After achievement of therapeutic effect it is necessary to reduce a daily dose to 1 g

Course of treatment in diseases of joints can last from 20 days to 2 months and more. At treatment of a pain syndrome the course of treatment lasts up to 7 days.

Overdose

Symptoms: pain in epigastric area, nausea, vomiting, drowsiness, a headache, it is rare - diarrhea, a disorientation, excitement, sonitus, a loss of consciousness, sometimes spasms (mefenaminovy acid tends to induction tonic - clonic spasms at overdose). In hard cases - gastrointestinal bleedings, respiratory depression, arterial hypertension, twitching of separate groups of muscles, a lump. In cases of considerable poisoning are possible a renal and liver failure.

Treatment: specific antidote is absent. Gastric lavage by suspension of activated carbon. Urine alkalizations, artificial diuresis. Symptomatic therapy. Hemosorption and a hemodialysis are ineffective because of strong linking of mefenaminovy acid with blood proteins. It is necessary to control carefully function of kidneys and a liver. Frequent or long spasms it is necessary to treat by means of intravenous administration of diazepam.

Structure

Active ingredient in one capsule - mefenaminovy acid - 250 mg

Excipients: talc; lactose, monohydrate; corn starch; sodium lauryl sulfate; silicon dioxide; magnesium stearate;

to Store

in original packing at a temperature not above 30 °C. To store out of children's reach.

Expiration date - 3 years.