Korvaltab of the Extra tab. of p/o No. 10

Pharmacological properties

Pharmacodynamics. vasodilating (koronarolitichesky), sedative, sleeping medicine. has soft anti-anginal effect. promotes decrease in excitability of central nervous system, has the calming effect and facilitates approach of a natural dream.

Ethyl ether of the α-bromizovalerianovy acid which is a part of medicine has spasmolytic, koronarolitichesky and sedative effect; in high doses causes also light somnolent effect.

Gvayfenezin causes anxiolytic (antidisturbing) action.

Docsilamin hydrogen succinate is a blocker of N ₁ - receptors and shows sedative, gipnogenny and antiallergic effects.

Pharmacokinetics. Gvayfenezin quickly (in 30 min.) is absorbed in a GIT. Mainly gets into the fabrics containing acid mucopolysaccharides. After intake With _max it is reached in 1–2 h, and therapeutic concentration remains during 6 h. T _½ gvayfenezina makes about 1 h. It is removed with a phlegm and allocated with kidneys in the form of metabolites and also in not changed look. With _max a docsilamin succinate hydrogen in blood plasma is reached on average in 2 h (T _max ) after administration of drug.

T _½ docsilamina from blood plasma averages 10 h

Docsilamin hydrogen succinate partially is metabolized in a liver by demethylation and N-acetylation. The t _½ can increase considerably at elderly people and at patients with a renal or liver failure. Various metabolites which are formed at disintegration of a molecule are not quantitatively significant as 60% of a dose define in urine in the form of not changed docsilamin.

Indication

Indistinct spasms of coronary vessels; neurocirculatory dystonia — in complex therapy; neurosis with acrimony; hyperexcitability; easy form of insomnia; dermatosis which is followed by an itch.

Use

by

Dosage and duration of a course of treatment is determined by the doctor individually for each patient. the adult, as a rule, appoint on 1 tablet of medicine 2–3 times a day to food. at an easy form of insomnia appoint on 1–2 tablets in 30 min. prior to a dream.

Contraindication

Hypersensitivity to components of medicine or antihistaminic drugs. heavy renal failures and liver, hepatic porphyria. glaucoma in the anamnesis of the patient or in the family anamnesis. uretroprostatichesky frustration with risk of an ischuria. heavy heart failure. depression and other frustration which are followed by oppression of activity of central nervous system.

Side effects

In some cases can arise such side effects:

from nervous system: drowsiness, slight dizziness;

from a digestive tract: nausea, vomiting;

from the immune system: allergic reactions (including skin rash, itch, small tortoiseshell).

Specified phenomena are eliminated with

at a dose decline or the termination of administration of drug.

At prolonged use of medicine in high doses the development of a bromism is possible

.

Diarrhea, a lock, dryness in a mouth, accommodation violation, the expressed heartbeat.

Day drowsiness: at development of such effect it is necessary to lower a dose.

rare messages about formation of concrements in a bladder or in kidneys for the patients accepting for a long time gvayfenezin in high doses Are available.

in case of undesirable side reactions should see consultation a doctor.

Special instructions

during administration of medicament needs to avoid consumption of alcoholic drinks.

Should be applied with care to patients of advanced age because of risk of developing of dizziness.

during treatment the syndrome of a night apnoea (increase in quantity and duration of apnoeas) can become aggravated.

urine discoloration is In some cases possible

.

should use Drug with care to such categories of patients with:

• chronic or continuous cough caused OH, smoking, chronic bronchitis and emphysema;
• renal failure;
• myasthenia gravis;
• acute gastrointestinal disorders.

Use during pregnancy and feeding by a breast. Drug is not appointed during pregnancy and feeding a breast.

Children. Experience of application for children is absent therefore medicament is not used in pediatric practice.

Ability to influence speed of response at control of vehicles or work with other mechanisms. For treatment it is necessary to abstain from driving or from the work with other mechanisms demanding speed of psychomotor reactions.

Interaction

At simultaneous application with other medicines oppressing central nervous system, perhaps mutual strengthening of action and also strengthening of effect of ethanol. influence of medicine amplifies against the background of alcohol intake.

Should consider

that in case of application of a combination of medicine with:

atropine and atropinopodobny medicines (antidepressants of an imipraminovy row, anticholinergic protivoparkinsonichesky medicines, atropinic spasmolytic medicines, Disopyramidum, fenotiazinovy neuroleptics) emergence of such side effects as an ischuria, a lock, dryness in a mouth is possible

• ;
• antidepressants derivative of morphine (the anesthetics and means applied to treatment at cough), neuroleptics; barbiturates, benzodiazepines, antihypertensive medicaments of the central action strengthening of oppression of central nervous system is possible.

Overdose

drowsiness, weakness, dizziness, vertigo, gastrointestinal disorders and signs of anticholinergic effects Are possible

: excitement, expansion of pupils, accommodation paralysis, dryness in a mouth, face reddening and necks, a hyperthermia, sinus tachycardia. use of medicine in very high doses can cause such symptoms as excitement, confusion of consciousness and respiratory depression.

Treatment: termination of administration of drug, gastric lavage and symptomatic therapy. There is no specific antidote.

Storage conditions

In original packing at a temperature not above 25 °C.

ACIN-PIM-122016-005