Glutargin solution for infection. 200mg/ml amp. 5 ml No. 10

Pharmacological properties

Pharmakodinamika.Glutargin — compound of arginine and glutaminic acid which play an important role in ensuring biochemical processes of neutralization and removal from an organism of a highly toxic metabolite of exchange of nitrogen-containing substances — ammonia. the gipoammoniyemichesky effect of medicament is implemented as a result of activation of processes of neutralization of ammonia in an ornitinovy cycle of synthesis of urea, binding of ammonia in a non-toxic glutamine and also strengthenings of removal of ammonia from central nervous system and its excretion from an organism. thanks to these properties glutargin reduces all-toxic and also neurotoxic effect of ammonia.

Glutargin has also hepatoprotective effect, has antioxidant, anti-hypoxemic and membrane stabilizing activity, positively influencing power supply of hepatocytes.

In a drunkenness utilization of alcohol in the monooksigenazny system of a liver, prevents oppression of key enzyme of utilization of ethanol — alcohol dehydrogenase; accelerates an inactivation and removal of toxic products of metabolism of ethanol as a result of increase in education and oxidation of succinic acid; reduces oppressing influences of alcohol on central nervous system due to neuromediator properties of glutaminic acid. Thanks to these Glutargin properties shows anti-toxic and sobering effects.

In pregnancy pathology, thanks to endoteliyprotektorny action, Glutargin normalizes the broken permeability and a tromborezistentnost of vessels, prevents hypercoagulation, reduces sensitivity of vessels to the vasoconstrictive agents (endothelin, angiotensin, thromboxane) causing a generalized vasospasm. Arginine after preliminary biotransformation in nitrogen oxide has vasodilating effect, positively influences fibrillation and functional properties of the circulating blood elements. As a result of vasodilating and anti-hypoxemic effects of Glutargin the maternal and fruit hemodynamics improves, the pre-natal hypoxia of a fruit decreases. In pregnancy pathology medicament shows also anti-toxic and gepatozashchitny activity, acts as the nonspecific metabolic regulator of exchange processes. Thanks to these properties of Glutargin during pregnancy the level of the cell-bound immune complexes circulating in blood decreases, the expressiveness of a syndrome of metabolic intoxication and immunotoxicosis decreases, compensatory and adaptive reactions of an organism increase.

embriotoksichesky, gonadotoksichesky, mutagen and teratogenic effects, does not cause allergic and immunotoxic reactions.

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Indication

as a part of complex therapy of acute and chronic hepatitises of various etiology, poisoning with hepatotrophic poisons (poison of a death angel, chemicals and medicines), in cirrhosis, damage of a liver in leptospirosis. hepatic encephalopathy, prekoma and coma which is followed by a giperammoniyemiya.

Condition of an acute drunkenness easy and moderately severe and also as a part of complex therapy of post-intoxication disorders after acute alcohol poisoning of heavy degree, including alcoholic encephalopathy and a coma. Prevention of intoxication and hepatotoxic action of alcohol.

Post-intoxication disorders, a hungover syndrome caused by alcohol intake.

Complication in the III trimester of pregnancy: a late gestosis, including its severe forms — a preeclampsia and an eclampsia, fetoplacental insufficiency, chronic pathologies of a gepatobiliarny system at pregnant women.

Use

Hepatitis, giperammoniyemiya.

Tablet. Orally appoint the adult 3 tablets on 0.25 g (0.75) or 1 tablet on 0,75 3 times a day within 15 days irrespective of meal. If necessary the dose of medicament and a course of treatment can be prolonged up to 20 days. The maximum single dose makes 2 g, the maximum daily dose — 8 g

Solution for injections (4%). Drug is appointed the adult in / century. Enter in into by drop infusion 2 once a day on 50 ml (2 g) into 150–250 ml of isotonic solution of sodium of chloride with a speed of 60-70 thaws of 1 min. In hard cases the daily dose of medicament is raised to 150–200 ml (6–8 g). A course of treatment — 5–10 days. The maximum daily dose — 200 ml (8 g).

Solution for injections (20%). Drug is appointed the adult in/in and in oil. Enter in into by drop infusion 1–2 once a day on 10 ml (2 g) on 150–250 ml of isotonic solution of sodium of chloride or 5% glucose solution with a speed of 60-70 thaws of 1 min. In hard cases the daily dose of medicament is raised to 30–40 ml (6–8 g) divided into 2 receptions. A course of treatment — 5–10 days. The maximum daily dose at in in introduction — 40 ml (8 g).

In oil the medicament is administered slowly deeply in a sciatic muscle by 1–2 times a day on 5 ml (1 g). If necessary the dose of medicament is raised to 10 ml (2 g) by 1–2 times a day. A course of treatment — 5–10 days. The maximum daily dose at introduction in oil — 20 ml of medicament (4 g).

Concentrate for preparation of solution for infusions

Drug is appointed the adult in/in in the form of infusions. Enter in into by drop infusion 2 once a day on 5 ml (2 g) into 150–250 ml of isotonic solution of sodium of chloride with a speed of 60-70 thaws of 1 min. In hard cases the daily dose of medicament is raised to 15–20 ml (6–8 g). A course of treatment — 5–10 days. The maximum daily dose — 20 ml (8 g).

Alcohol poisoning.

Tablet. Appoint on 4 tablets on 0.25 g (1.0 g) or 1 g 4 times a day with an interval of 1-2.5 h, in the next 2–3 days — 2 tablets on 0.25 g (0.5 g) or ½ on 1 g 3 times a day. In a drunkenness of heavy degree after a course of treatment injection medicaments of Glutargin appoint Glutargin's tablets 3 tablets on 0.25 g (0.75 g) or 1 tablet on 0.75 g 2 times a day, or 1 ¹ / ₂ tablets on 1 g of 1 times a day within 20 days. For prevention of a drunkenness — 2 g in 60–120 min. prior to alcohol intake.

Powder for oral solution

Drug is appointed the adult inside, previously having dissolved a package in ¼–½ glasses of water.

For prevention of intoxication and hepatotoxic action of alcohol are appointed by 2 g (2 packages) for 1–2 h before alcohol intake or 1 g (1 package) for 1 h before alcohol intake and 1 g (1 package) for 0.5 h after alcohol intake. For treatment of an acute drunkenness easy and moderately severe appoint 1 g (1 package) 4 times a day with intervals of 1-2.5 h, in the following 2–3 days — on 1 g (1 package) 2 times a day. In a drunkenness of heavy degree the powder Glutargin alkoklin is appointed on 1 g (1 package) by 2 times a day for 20 days as a part of complex therapy after a course of treatment injection forms of the medicament Glutargin.

Solution for injections (4%). For treatment of a drunkenness appoint 20 ml (0.8 g), enter by drop infusion into 150–250 ml of isotonic solution of sodium of chloride with a speed of 60-70 thaws of 1 min. of 2 times a day for 2–3 days, then the dose is reduced to 10 ml (0.4 g) by 2 times a day within 10 days. In hard cases (alcoholic coma) the daily dose is raised to 50 ml (2 g) by 2 times a day.

After a course of treatment with solution for Glutargin's injections/infusions to reception of tablets of Glutargin.

Solution for injections (20%). Drug is appointed the adult in/in and in oil. Enter in into by drop infusion 2 once a day on 4 ml (0.8 g) on 150–250 ml of isotonic solution of sodium of chloride or 5% glucose solution with a speed of 60-70 thaws of 1 min. In 2–3 days the dose is reduced to 2 ml (0.4 g).

In oil the medicament is administered slowly deeply in a sciatic muscle on 4 ml (0.8 g) by 2 times a day for 2–3 days, then the dose is reduced to 2 ml (0.4 g) by 2 times a day for 5–10 days. In hard cases (alcoholic coma) in/in or introductions in oil raise a daily dose to 10 ml (2 g) 2 times a day.

Concentrate for preparation of solution for infusions

For treatment of alcohol poisoning is appointed in/in on 2 ml (0.8 g), entered by drop infusion into 150–250 ml of isotonic solution of sodium of chloride with a speed of 60-70 thaws of 1 min. of 2 times a day for 2–3 days, then the dose is reduced to 1 ml (0.4 g) by 2 times a day within 10 days. In hard cases (alcoholic coma) the daily dose is raised to 5 ml (2 g) by 2 times a day.

After a course of treatment of 40% with Glutargin's solution to reception of the tablets Glutargin.

Pathology of pregnancy

Tablet. Appoint 0.25-0.5 g (1–2 tablets on 0.25 g) 2–3 times a day within 10–15 days. If necessary the single dose of medicament can be raised to 0.75 g (3 tablets on 0.25 g or 1 tablet of 0.75 g), a course of treatment — up to 20 days. The highest single dose makes 0.75 g, the highest daily — 2.25 g

Solution for injections (4%). Enter 1–2 times a day 50 ml (on 2 g). A course of treatment — 5–7 days the Highest daily dose — 100 ml (4 g).

Concentrate for preparation of solution for infusions. Enter by drop infusion 1–2 times a day on 5 ml (2 g) on 150–250 ml of isotonic solution of sodium of chloride with a speed of 60-70 thaws of 1 min. A course of treatment — 5–7 days. The maximum daily dose — 10 ml (4 g).

Contraindication

Relative contraindications are feverish states, hyperexcitability, heavy disturbances of filtrational (azotovydelitelny) function of kidneys.

Side effects

Tablet: seldom — feeling of slight discomfort in a stomach and intestines, nausea directly after administration of drug, withdrawing.

Solution for injections/infusions: are seldom possible — the significant weakness, an asthma, a retrosternal pain, a fever, disturbance of a heart rhythm in the form of an atrial fibrillation, hypotension, a Quincke's edema. In isolated cases — easy allergic reactions (urticaria, hyperaemia, an itching).

Special instructions

When assigning that medicament is capable to stimulate secretion of insulin and growth hormone.

Children. Experience of use of medicament for children is insufficient.

Influence on ability of control of vehicles and work with difficult mechanisms.

Tablet: does not influence.

Solution: as during treatment there can be side reactions from central nervous system (headache, dizziness, a tremor) it is necessary to be careful at control of transport or work with other mechanisms.

At simultaneous use with Aminophyllinum the increase in concentration of endogenous insulin in blood is possible

Interaction. glutargin can enhance effect of anti-aggregation means (Dipiridamolum, etc.). warns and reduces expressiveness of the neurotoxic phenomena which can arise at use of an isoniazid. reduces effect of vinblastine.

Overdose

Symptoms: pain in a thorax, av-blockade.

Treatment: in this case it is shown in/in introduction of GKS. Symptomatic therapy.

Storage conditions

Tablet in original packing at a temperature not above 25 °C, solution for infection. in original packing at a temperature of 25 °C, konts. for inf. solution in the place protected from light at a temperature of 25 °C.

Relevant information

Glutargin — medicament which is the nonspecific regulator of metabolism with primary hepatoprotective and anti-toxic action. active ingredient of this medicament is necessary for many chemical and biological processes in an organism that causes need of its appointment at injuries of central nervous system and cells of a liver by various poisons and toxins, at disturbances of a capillary blood-groove, hard cases of multiorgan insufficiency.

Medical effect Glutargin is implemented at the expense of active agent — an arginine glutamate. For the different purposes is issued in the injection and tableted form. For parenteral administration the concentrate for solution for infusions of 400 mg/ml an ampoule of 5 ml, solution for injections of 40 mg/ml an ampoule of 5 ml, solution for injections of 200 mg/ml an ampoule of 5 ml is issued. Tablets are issued in two options, convenient for a dosage: 250 or 750 mg (instruction of MZ of Ukraine).

Pharmakodinamichesky characteristics of medicament are defined by combination of therapeutic effect of glutaminic acid and arginine. Glutaminic acid belongs to the most widespread replaceable amino acids (it is synthesized in an organism and arrives from the outside with food). Therefore it is involved in many various biological processes. Glutaminic acid — one of important factors of transfer of a nervous impulse in synapses, has exciting effect on central nervous system that is widely used in neurotoxicoses of various genesis. Also glutaminic acid is starting material for formation of endogenous folic acid. Especially often these characteristics of glutaminic acid are used at treatment of poisoning with low-quality alcohol. Besides function of the neurotransmitter, glutaminic acid influences the monooksigenazny system of hepatocytes (alcohol metabolism, removal of toxic metabolites), interferes with alcohol dehydrogenase blocking.

Besides, with a glutamine connected synthesis of difficult proteinaceous components of connective tissue, nitrogen transport, a gluconeogenesis and acid osnovny a homeostasis. The cytoprotective effect of amino acid is implemented via mechanisms of activation of a nuclear factor NF-kB, balance between about - and anti-inflammatory cytokines, decrease in accumulation of neutrophils, protection against an oxidative stress (Yuan Wang, 2019). The last mechanism is especially important at risk of development of a septicaemia and multiorgan insufficiency. Besides, multiple researches proved need of presence of this amino acid for hepatocytes at formation of antioxidants; value of its education in regulation and secretions of bile acids, trophicity of cells of a liver; in regulation of education and emission of a glycogen, lipids and insulin (Emanuele Therezinha Schueda STONOGA, 2019).

to NO ₂ , improves blood circulation by elimination of a spasm of a capillary bed, and together with a glutamate is a neurotransmitter. Due to effect of a vazodilatation the general endurance of an organism improves and especially blood supply of a myocardium improves. Arginine promotes decrease in insulin resistance during pregnancy, stimulates exchange processes in a placenta (Morgane Robles, 2019). Participation also belongs to effects of arginine in:

• ureapoiesis cycle;

• collagen synthesis;

• synthesis of the reserve carrier of cellular energy — phosphoarginine;

• and also stimulation of production of hormones (Somatotropinum, insulin), neurotransmitters (serotonin, adrenaline);

• potentiation of effect of hypotensive medicaments due to elimination of a capillary spasm;

• acceleration of angenesis due to improvement of supply with their oxygen.

at pathological processes in the late stages of pregnancy. It promotes stabilization of permeability and a tromborezistentnost of vessels, interferes with hypercoagulation and a generalized vasospasm. Glutargin improves a fetoplacental hemodynamics (vasodilating and anti-hypoxemic mechanisms), development is interfered by a distress syndrome at a fruit. Besides, medicament allows to raise compensatory and adaptive mechanisms in the woman's organism during incubation of the child.

Besides therapy, Glutargin professional athletes can apply to improvement of quality of muscle tissue. Besides, it is recommended to the people weakened after serious illnesses to appoint Glutargin for the early recovery.