Ftalazol-Darnitsa tab. of 500 mg No. 10

Pharmacological properties

Phthalylsulfathiazole (2 (couples-ftalilaminobenzolsulfamido) - thiazol) — the sulfanamide medicament having bacteriostatic action which mechanism is caused by disturbance of synthesis in microorganisms of their growth factors — folic and dihydrofolic acids. it is slowly absorbed from a digestive tract at intake, the main amount of medicament is late in intestines where an active (sulfanamide) part of a molecule is gradually chipped off. the high concentration of medicament reached thus in intestines taking into account specific bacteriostatic activity concerning indestinal flora causes high efficiency of phthalylsulfathiazole in intestinal infections. medicament malotoksichen.

Indication

Acute dysentery, chronic dysentery in an aggravation phase, colitis, including ulcer, a coloenteritis, a gastroenteritis, intestinal surgeries (for prevention of purulent complications), amoebic dysentery and a paratyphoid infection (as supportive application).

Use

Inside. in acute form of dysentery the adult appoint in 1–2 — y day — 6 g/days (each 4 h on 1 g), in 3–4 — y day — on 4 g/days (each 6 h on 1 g), in 5–6 — y day — on 3 g/days (each 8 h on 1 g). the course dose makes 25–30 g in 5–6 days after the 1st course of treatment conduct the 2nd course: 1–2 — y day — on 1 g in 4 h (at night — in 8 h), only 5 g a day; 3–4 — y day — on 1 g in 4 h (to night do not appoint), only 3 g a day. the general dose on the 2nd course — 21 g; at the easy course of the disease it is possible to lower it to 18 g the highest doses for adults inside: single — 2 g, daily — 7 g to children under 3 years appoint medicament at the rate of 0.2 g/kg a day; the daily dose is divided during the day into 3 equal parts accepted during wakefulness. in the specified dose the medicament is taken within 7 days. to children 3 years are more senior (depending on age) appoint 0.4-0.75 g to reception 4 times a day.

In other diseases medicament are appointed by the adult in the first 2–3 days on 1–2 g by each 4–6 h, in the next 2–3 days — in a half dose. To children appoint in 1 — y day at the rate of 0.1 g/kg a day. The medicament is taken in equal doses by each 4 h with a break for the night. In the next days each 6–8 h

Contraindication

Hypersensitivity to drug, a bazedova a disease, blood diseases, an acute hepatitis appoint 0.2-0.5 g.

Side effects

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Special instructions

With care the patient with a nephrosis, nephrite.

Interaction

Depending on the nature of a disease can use medicament in combination with antibiotics. along with Ftalazolum-darnitsa it is reasonable to appoint well soaking up streptocides — Sulfadimezinum, Etazolum, etc. Ftalazolum-darnitsa is incompatible with salicylates, pask, dipheninum (strengthening of toxicity of phthalylsulfathiazole), Oxacillinum (Oxacillinum decrease of the activity), nitrofurans (increase in risk of developing anemia and methemoglobinemia), medicaments women's and male sex hormones (oppression of function of gonads), Calcii chloridum and vitamin K (decrease in blood clotting).

Storage conditions

In the dry place.