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- Model: 178610
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Reviews Over Eufillin-Zdorovye solution for infection. 20mg/ml amp. 5 ml No. 10
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Description
medicament "Eufillin-Zdorovye" is used at the following indications: a bronkhoobstruktivny syndrome at bronchial asthma, bronchitis, emphysema of lungs, violations from a respiratory center (night paroxysmal an apnoea), "pulmonary heart".
Structure
Active ingredient - theophylline (1 ml of solution contains monohydrate theophylline in terms of theophylline 20 mg).
Excipients: sodium acetate, trihydrate; sodium hydroxide; water for injections.
Contraindication
- hypersensitivity to medicine components, other derivatives of xanthine (caffeine, pentoksifillin, theobromine);
- an acute heart failure, dekompensirovanny chronic heart failure, stenocardia, a sharp myocardial infarction, a Bouveret's disease, premature ventricular contraction, heavy arterial hyper - and hypotension, widespread atherosclerosis of vessels, a fluid lungs, a hemorrhagic stroke, an eye retinal apoplexy, bleeding in the anamnesis, a peptic ulcer of a stomach and duodenum in an aggravation stage, a gastroesophageal reflux, epilepsy, glaucoma, the increased convulsive readiness, an uncontrollable hypothyroidism, a hyperthyroidism, a thyrotoxicosis, a heavy liver and/or renal failure, a porphyria, sepsis, application to children along with ephedrine.
Route of administration
to administer the Drug intravenously. To select a dose individually, considering a possibility of various rate of administering.
If the patient takes the theophylline medicaments inside, the theophylline dose for parenteral administration should be reduced.
At medicine introduction the patient has to be in a prone position; the doctor has to control arterial blood pressure, heart rate, respiration rate and the general condition of the patient. To prepare solution just before application: for jet introduction a single dose of medicine to dissolve in 10-20 ml 0.9% of solution of sodium of chloride, for intravenous drop administration - in 100-150 ml of 0.9% of solution of sodium of chloride.
Intravenously struyno to enterslowly (within not less than 5 minutes), intravenously by drop infusion - with a speed of 30-50 thaws/minute.
a dose to expectAt medicine introduction theophylline in milligrams, considering that 1 ml of medicine contains 20 mg of theophylline.
Adult intravenously struyno to enter in a daily dose 10 mg/kg of the body weight (on average - 600-800 mg) divided into 3 introductions. At a cachexia and at persons with initial low body weight to reduce a daily dose to 400-500 mg, at the same time during the first introduction to enter no more than 200-250 mg. At emergence of acceleration of heartbeat, dizziness or nausea rate of administering to reduce or pass to introduction intravenously by drop infusion.
to Children aged from 14 years intravenously by drop infusion in a dose of 2-3 mg/kg of body weight. The maximum daily dose for children of 14 years - 3 mg/kg of body weight.
Maximum daily doses which can be applied without control of concentration of theophylline in blood plasma:
- children at the age of 3-9 years - 24 mg/kg of body weight;
- children at the age of 9-12 years - 20 mg/kg of body weight;
- children at the age of 12-16 years - 18 mg/kg of body weight;
- patients are more senior than 16 years - 13 mg/kg of body weight (or 900 mg).
Highest doses for adults. Intravenously: single - 250 mg, daily - 500 mg.
Highest doses for children. Intravenously: single - 3 mg/kg of body weight.
Duration of treatment depends on weight and a course of the disease, sensitivity to therapy, but should not exceed 14 days.
toPregnant
toDrug is contraindicated to
Feature of application
during pregnancy. In need of use of medicine the feeding by a breast should be stopped.Children
not to use Drug for introduction to children up to 3 years. To children aged from 3 years the use of medicine is possible according to vital indications, but not longer than 14 days.
DriversConsidering
that sensitive patients at use of medicine can have side reactions (dizziness and others), during use of medicine it is necessary to refrain from control of vehicles and performance of other works demanding concentration of attention. Overdose
At fast introduction spasms, arrhythmias, heavy hypotension, stenocardia are possible
. At concentration of theophylline in blood plasma more than 20 mg/ml (110 µmol/l) are observed nausea, vomiting (numerous vomiting, sometimes with blood, can lead to dehydration), diarrhea, excitement, a tremor, arterial hypertension, a hyperventilation, supraventricular and ventricular arrhythmias, arterial hypotension, a coma, spasms, metabolic frustration (hypopotassemia, a hypercalcemia, a hypophosphatemia, a hyperuricemia, a hyperglycemia, a metabolic acidosis, a respiratory Alkalosis). Other toxic manifestations include dementia, toxic psychosis, symptoms of sharp pancreatitis, a rhabdomyolysis with a renal failure.
Treatment: depends on expressiveness of symptoms and includes medicament withdrawal, correction of a hemodynamics, stimulation of removal of theophylline from an organism (artificial diuresis, hemosorption, a plazmosorbtion, a hemodialysis, peritoneal dialysis), purpose of symptomatic means, oxygenotherapy, artificial ventilation of the lungs. To apply diazepam to knocking over of spasms. Use of barbiturates is inexpedient. It is necessary to avoid at ventricular arrhythmias use of such antiarrhytmic medicines which possess anticonvulsant action as lidocaine, because of risk of exacerbation of spasms.
serumal concentration of medicine should be supported byFor efficiency and safety within 10-15 mg/kg, in the absence of a possibility of definition of concentration of theophylline in blood, its daily dose should not exceed 10 mg/kg.
Side effects
from nervous system: dizziness, a headache, concern, uneasiness, excitement, irritability, a sleep disorder, a tremor, spasms, a confusion/loss of consciousness, insomnia (especially at children), nonsense, hallucinations, presinkopalny a state.
from digestive tract: stomach aches, nausea, vomiting, gastroesophageal reflux, heartburn, exacerbation of a peptic ulcer, stimulation of secretion of gastric juice, intestines atony, diarrhea; at prolonged use - a loss of appetite.
Metabolic violations: metabolic acidosis, hypopotassemia, hypercalcemia, hyperuricemia, hyperglycemia, violation of acid-base equilibrium of blood, rhabdomyolysis.
from a cardiovascular system: arrhythmias, heartbeat, tachycardia, a lowering of arterial pressure, shock, a cardialgia, increase in frequency of attacks of stenocardia, premature ventricular contraction (ventricular, supraventricular), heart failure, collapse (at fast introduction).
from an urinary system: increase in a diuresis (owing to increase in glomerular filtration), at patients of advanced age is urination difficulty (owing to a detruzor relaxation).
from the immune system: allergic reactions, including rash, an itch, urticaria, exfoliative dermatitis, a Quincke's disease, a bronchospasm, an acute anaphylaxis.
Reaction in the injection site: hypostasis, hyperaemia, pain, consolidations.
Interactionnot to apply
in one syringe with other injection medicines, except for 0.9% of solution of sodium of chloride, in connection with pharmaceutical incompatibility. Drug cannot be used with solutions of glucose, fructose (levulose).
needs to be considered rn solutions which are applied together with medicine: pharmaceutical medicine is incompatible with solutions of acids.
Storage conditionsto Store
in original packing at a temperature not above 25 °C, out of children's reach.
Expiration date - 3 years.
Specifications
Characteristics | |
Active ingredients | Theophylline |
Amount of active ingredient | 20 mg/ml |
Applicant | Health |
Code of automatic telephone exchange | R03DA04 Theophylline |
Interaction with food | It doesn't matter |
Light sensitivity | Not sensitive |
Market status | The branded generic |
Origin | Chemical |
Prescription status | According to the prescription |
Primary packing | ampoule |
Producer | TOB PHARMACEUTICAL COMPANY HEALTH |
Quantity in packing | 10 ampoules on 5 ml |
Release form | solution for injections |
Route of administration | Intravenous |
Sign | Domestic |
Storage temperature | from 5 °C to 30 °C |
Trade name | Euphyllinum |