Depiofen of the tab. of p/o of 25 mg No. 10

Tablets film coated Depiofen are shown at short-term symptomatic treatment of an acute pain easy and moderate severity, for example, musculoskeletal pains, painful periods (dysmenorrhea), a toothache.

Structure

Active ingredient: deksketoprofena trometamol;

1 tablet supports a deksketoprofen to a trometamol is equivalent a deksketoprofena of 25 mg;

Excipients: corn starch, cellulose microcrystalline, starch sodium (type A), silicon dioxide colloidal, magnesium stearate;

Cover of a tablet of the titan dioxide (E 171), gipromelloza, polyethyleneglycol 6000, talc.

Contraindication

• hypersensitivity to a deksketoprofen, any other NPVP (NPVS) or to medicament excipients;
• if substances of similar action, for example acetylsalicylic acid or other NPVS, provoke development of attacks of asthma, a bronchospasm, acute rhinitis or cause development of nasal polyps, appearance of a small tortoiseshell or a Quincke's disease;
if photoallergic and phototoxic reactions were known to
• during treatment for ketoprofen or fibrata;
• gastrointestinal bleeding or perforation in the anamnesis connected with the previous therapy of NPVP;
• an active phase of a peptic ulcer / gastrointestinal bleeding or gastrointestinal bleeding, a peptic ulcer, perforation in the anamnesis;
• chronic dyspepsia;
• other bleedings in an active phase or the increased bleeding;
• Crohn's disease or ulcer colitis;
• heavy heart failure;
• renal failure of average or heavy degree (clearance of creatinine ≤ 59 ml/min.);
• a heavy abnormal liver function (10-15 points on a scale of Chayld-Pyyu);
• in hemorrhagic diathesis and at other disturbances of fibrillation;
• at heavy degree of dehydration, caused by vomiting, diarrhea or insufficient consumption of liquid;
• III trimester of pregnancy and feeding by a breast.

Route of administration

Adult. Depending on a look and intensity of pain the recommended dose makes 12.5 mg each 4-6 hours or to 25 mg there are each 8 hours. The daily dose should not exceed 75 mg. The undesirable phenomena of medicament can be minimized by use of minimum effective doses during shorter period necessary for elimination of symptoms. Depiofen not is provided for long therapy the treatment has to be is limited to time existence of symptoms. The concomitant use of food reduces the speed of absorption of active ingredient therefore the minimum in 30 minutes prior to meal is recommended to accept it.

Feature of use

Pregnant

It is contraindicated in the III trimester of pregnancy. Uses of medicament in the I and II trimesters of pregnancy it is possible only if the expected advantage for mother exceeds possible risk for a fruit, and the dose and duration of treatment should be reduced to a possible minimum.

Children

should not be applied.

Drivers

With care.

Symptomatology of overdose is unknown to

. Similar medicines cause disturbances from a digestive tract (vomiting, anorexia, an abdominal pain) and nervous system (drowsiness, dizziness, a disorientation, a headache).

should begin with

At accidental overdose immediately symptomatic treatment according to a condition of the patient. Deksketoprofen is brought from an organism by means of dialysis.

Side effects

from a digestive tract: nausea, vomiting, an abdominal pain, dyspepsia, diarrhea, a constipation, vomiting with blood impurity, dryness in a mouth.

Interaction

Other NPVP, including selection inhibitors of cyclooxygenase-2 and salicylates in high doses (≥3 g/days). At simultaneous use of several NPVP the risk of developing of an ulcer in a digestive tract and gastrointestinal bleeding owing to their mutual strengthening of action increases.

NPVS Anticoagulants strengthen effect of anticoagulants, for example warfarin, because of high extent of linking of a deksketoprofen with proteins of blood plasma and also oppression of function of thrombocytes and injury of a mucous membrane of a stomach and a duodenum. If simultaneous use is necessary, it should be seen off under observation of the doctor and control of the corresponding laboratory indicators.

Heparin increases risk of developing bleedings (oppression of function of thrombocytes and injuries of a mucous membrane of a stomach and a duodenum). If simultaneous use is necessary, it should be seen off under observation of the doctor with control of the corresponding laboratory indicators.

to Store

at a temperature not above 30 °C in original packing for protection against effect of light.

to Store

out of children's reach.

Expiration date - 2 years.