CIPROCOLIN powder 100 ml

CIPROCOLIN is a homogeneous powder of white or light yellow color, after dissolution - a solution of light yellow color with opalescence.

Composition

1 bottle contains active ingredients: ciprofloxacin (in the form of hydrochloride) - 1000 mg; colistin sulfate - 10,000,000 IU.

Excipients: ascorbic acid, sodium bicarbonate, sucrose, aerosil, flavor.

Pharmacological properties

CIPROCOLIN is a complex drug, the therapeutic effect of which is due to the synergistic effect of the active components of the drug: ciprofloxacin and colistin sulfate.

Ciprofloxacin belongs to the group of fluoroquinolones. The mechanism of action of ciprofloxacin consists in inhibiting bacterial DNA gyrase, which interferes with the process of DNA replication, thereby disrupting the integrity of the bacterial cell membrane, which leads to its death. Ciprofloxacin hydrochloride rapidly eliminates R-plasmids, which prevents the development of resistance of microorganisms to the drug.

The drug is active against gram-negative and gram-positive microorganisms, and especially against E. coli, Salmonella spp., Shigella spp., Enterobacter spp., Klebsiella spp., Proteus spp., Serratia spp., Campylobacter spp., Pseudomonas aeruginosa, Yersinia spp. Vibrio spp., Aeromonas spp., Haemophilus spp., Are also sensitive to the drug: Brucella spp., Staphylococcus spp. (including strains producing penicillinase and methicillin-resistant strains), Mycoplasma spp., Mycobacterium spp., Chlamydia spp.

With oral administration of the drug, ciprofloxacin is rapidly absorbed from the alimentary canal, entering the bloodstream, penetrating into all organs and tissues of the body, reaching a maximum concentration after 1-2 hours, the therapeutic concentration is maintained for 24 hours. Ciprofloxacin is excreted from the animals body with urine and bile.

Colistin sulfate is an antibiotic of the polymyxin group, which is synthesized by the aerobic spore-forming bacillus Bacillus polymyxa. Colistin sulfate has a bactericidal effect on gram-negative bacteria (E. coli, Salmonella spp., Pasteurella spp., Haemophilus spp., Bordetella spp.).

Colistin sulfate binds to the phospholipids of the cytoplasmic membrane, enhances its permeability to both intra- and extracellular components, which leads to the destruction of the bacterial cell.

After oral administration, colistin sulfate is slightly absorbed from the alimentary canal. Unlike low concentrations of colistin sulfate in blood serum and tissues, high and constant concentrations of it are always present in different parts of the digestive tract. Colistin sulfate is excreted in the faeces of the animal.

Application

The drug is used for therapeutic purposes in dogs and cats with acute and chronic bacterial infections, the causative agents of which are sensitive to ciprofloxacin and colistin (infections of the digestive tract, respiratory tract, biliary tract, genitourinary system, skin and soft tissues, eyes and ears, bones and joints); and with secondary infections against the background of viral diseases.

Dosage

Before using the drug, a solution is prepared from the powder. For this, 100 ml of drinking water at room temperature (up to the mark) is poured into a bottle with a powder and vigorously shaken until the powder is completely dissolved.

The required amount of the resulting solution is drawn up with a dosing syringe.

The resulting solution is administered orally to dogs and cats in doses: 1 ml per 1 kg of body weight of the animal 1 time per day. The course of treatment is 3-5 days.

Before each next use, the bottle is vigorously shaken.

Cautions

It is not recommended to use:

puppies and kittens before the end of the growth period due to the risk of damage to cartilage tissue;

animals with severe developmental disorders of cartilage tissue;

with lesions of the nervous system, which are accompanied by convulsions;

females during pregnancy and lactation.

Do not use in case of increased individual sensitivity to the components of the drug.

Do not use in conjunction with nonsteroidal anti-inflammatory drugs, macrolide antibiotics, tetracycline and chloramphenicol.

Release form

Polymer bottles, 100 ml.

Storage

The shelf life is 3 years. Store in a dry, dark place out of the reach of children at a temperature of 5 to 25 ° C. The shelf life after dilution is 7 days.

Characteristics CIPROCOLIN powder 100 ml

A type

Antibiotics

Kind of animal

Cats

Dogs

Appointment

For eyes

For the biliary tract

For skin

For the genitourinary system

For soft tissues

To treat wounds

For respiratory organs

For joints

For ears

Dosage form

Powder

Volume, ml

one hundred

Country of origin

Ukraine

Brand registration country

Ukraine