Atsik cream of 5% of a tube of 2 g

Atsik Cream

Herpes — one of the most widespread viral infections of the person. The virus infected more than 90% of the population of the planet. Lips and face skin often suffer from a herpes infection (Herpes labialis). Herpes ointment helps to reduce the term of treatment and reduces expressiveness of clinical manifestations of herpes of lips. This description is made on the basis of the official instruction for use of Atsik cream from the producer.

Relevant information

Acyclovir — the conventional "gold standard" of antiherpetic therapy. It is safe for people of all age groups. Drug intake is limited only for children up to 12 years owing to lack of data on conduct of clinical trials in pediatrics.

Primary contact with a gerpesny infection at most of people happens in the early childhood. The virus remains in an organism for life, and the had person is the carrier of an infection and often suffers from a recurrence. HSV (herpes simplex virus) can spontaneously be activated, without the reasons seen on that. However usually the recurrence requires the trigger. Such factors can induce virus inflammation:

• decrease in protective forces of an organism;
• change of climate, insolation;
• stress;
• overheating, overcooling;
• feverish state;
• hormonal imbalance;
• intake of immunosuppressive medicines;
• a trauma mucous and skin;
• sharp respiratory viral diseases, etc.

Pathogenesis (development mechanism) of a herpes infection is based on ability of VPG is long to be in nervous gangliya (to persistirovat) in the sleeping state throughout all human life. Virus DNA cannot be removed from neurons with any of ways known today. However there are means which inactivate ability of a virus genome to division. Acyclovir belongs to such substances.

Pharmacotherapeutic group

Atsik Cream — antiviral means for topical administration.

Structure and a form of release

Atsik — external use cream.

Main operating component — acyclovir. 1 g of cream contains 50 mg of acyclovir.

Additional substances:

• stearilpolioksilglitserid;
• dimetikon 350;
• cetyl alcohol;
• paraffin white soft;
• oil mineral;
• propylene glycol;
• water purified.

"Atsik cream of 5%" Physical and chemical properties release in tubas on 2 g

Cream from herpes of Atsik has uniform creamy consistence, without lumps, other inclusions. Signs of division into fractions are absent. Color is white or milk.

Chemical name of acyclovir: 2-amino-9-marked (2-hydroksietoks)) - 1.9 - dihydro-6H - purine - 6 - it

Chemical formula of substance acyclovir: C8H11N5O3

Pharmacological properties

Pharmacodynamics

Acyclovir — antiviral medicine for topical administration, is highly active in vitro concerning a virus of a herpes simplex of the 1st and 2nd types. Toxic action concerning cages of an organism of the owner minimum. Getting into the cells infected with a herpes virus, acyclovir is phosphorylated with formation of active connection — acyclovir triphosphate. The first stage of this process depends on existence of a virusokodirovanny thymidinekinase. Triphosphate of acyclovir works as inhibitor and substrate for a virus DNA polymerase, preventing further synthesis of virus DNA, not influencing usual cellular processes.

Pharmacokinetic researches showed to

minimum level of system absorption of acyclovir after repeated topical administration of cream.

Indication

Treatment of infections of the lips and the person caused by a virus of a herpes simplex (Herpes labialis).

Contraindication

Hypersensitivity to acyclovir, a valatsiklovir, propylene glycol or other components of cream.

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only for external use.

needs to apply Atsik cream to Adults and children at the age of 12 years with

5 times a day (with an interval of 4 h), except for night time. It is important to begin treatment as soon as possible at the beginning of an infection, it is the best of all — during a prodromal stage or at an erythema stage.

Treatment has to last at least 4 days. If healing is noted, it is possible to continue treatment up to 10 days. If symptoms of a disease do not disappear after 10 days of treatment, the patient needs to see a doctor.

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Overdose

At accidental oral or topical administration of all contents of a tube of cream of an adverse effect it is not revealed because of the minimum system influence. In case of suspicion on overdose it is necessary to ask for medical care.

Possible symptoms of intoxication:

• symptoms of dyspepsia: nausea, desires to vomiting, diarrhea;
• headache;
• dizziness;
• short wind;
• drowsiness.

Treatment:

• First-aid treatment (washing of a GIT, activated carbon).
• Symptomatic therapy.

Side effects

At some patients at use of cream can appear temporary fast-passing sharp or a thermalgia. Approximately at 5% of patients noted insignificant drying and peeling of skin. At a small part of patients noted an erythema (reddening) and the naggers. It was very seldom reported about cases of contact dermatitis after use of cream. When carrying out tests for sensitivity these cases more often were connected with components of a cream basis, but not with acyclovir. There are single messages about early reactions, including a Quincke's disease owing to topical administration of acyclovir.

Special instructions

should apply Cream only to treatment of herpes on lips and a face. It is not recommended to apply cream on mucous membranes of an oral cavity, an eye and to apply it to treatment of genital herpes. It is necessary to avoid accidental hit of cream in eyes.

. The faces sore with herpes, it is necessary to warn against contact transfer of a virus to other people, especially in the presence of open defeats (for example, to wash hands before cream use). It is not recommended to apply at patients with an immunodeficiency. Such persons need consultation of the doctor concerning treatment of any infection.

cream should be applied To achievement of the best success of treatment already at emergence of the first symptoms of an infection of herpes (burning, the naggers, feeling of tightness and reddening). Virostatichesky treatment using Atsik cream is inexpedient when integuments crust.

Use during pregnancy and feeding by a breast

during pregnancy and feeding by a breast medicament is recommended to be used only when the advantage, according to the doctor, exceeds risk.

Children

Data on safety of use of medicine for children at the age of 12 years therefore it is recommended to apply at children aged 12 years are more senior.

Advanced age

Contraindications to prescribing of Atsik cream.

Use at abnormal liver functions, kidneys

Restriction are absent, the dose decline is not required.

Ability to influence speed of response at control of vehicles or work with other mechanisms

Data.

Interaction with other medicines

Sharing with the medicines stimulating the immune system improves effect of acyclovir.

Storage conditions

At a temperature not above 25 °C. Not to freeze! To store out of children's reach. A cream expiration date — 4 years from the moment of release.

Category of a holiday

Atsik Cream — OTC medicine.

List of the used literature

1. Reference book of medicines the Compendium.
2. JAMA