Atorvakor of the tab. p / captivity. obol. 20 mg No. 40

tablets Atorvakor are shown for:

• prevention of cardiovascular diseases;
• reduction of risk of developing of a myocardial infarction;
• reduction of risk of developing of a stroke;
• reduction of risk of holding procedures of revascularization and stenocardia.
• reduction of risk of developing of a non-lethal myocardial infarction;
• reduction of risk of developing of a lethal and non-lethal stroke;
• reduction of risk of hospitalization in connection with stagnant heart failure.

Structure

Active ingredient: atorvastatin;

1 tablet supports an atorvastatin of calcium of trihydrate of 10.82 mg, either 21.64 mg, or 43.28 mg, or 86.56 mg in terms of 100% substance (that is equivalent to an atorvastatin) 10 mg, or 20 mg, or 40 mg, or 80 mg;

Excipients: calcium carbonate; lactose, monohydrate; microcrystalline cellulose; sodium of a kroskarmeloz; polysorbate 80, hydroxypropyl cellulose; magnesium stearate; Opadry II 85F18422 white (polyvinyl alcohol, polyethyleneglycol, talc, titan dioxide (E 171)).

Contraindication

• Active disease of a liver which can include steady increase in activity of hepatic transaminases of not clear etiology.
• Hypersensitivity to any of components of this medicine.
• Period of pregnancy and feeding by a breast.
• Woman of childbearing age which do not use contraceptives.

Route of administration

Recommended initial dose of the medicament Atorvakor makes 10 or 20 mg of 1 times a day. For the patients demanding considerable decrease in level of LDL cholesterol (more than for 45%), therapy can be begun with a dosage of 40 mg of 1 times a day. Dose range of the medicament Atorvakor is ranging from 10 up to 80 mg of 1 times a day. The medicament can be taken a single dose in any hours and irrespective of meal. Initial and maintenance doses of the medicament Atorvakor have to be picked up individually, depending on the purpose of treatment and the answer. After an initiation of treatment and/or after titration of a dose of the medicament Atorvakor it is necessary to analyze levels of lipids during the period from 2 to 4 weeks and as appropriate to modify a dose.

Feature of use

Pregnant

It is contraindicated.

Children

Since 10 years.

Drivers

is Carried out by very insignificant influence on speed of response at control of motor transport or work with other mechanisms.

Overdose

Specific treatment of overdose of an atorvastatin. In case of overdose of the patient it is necessary to treat symptomatically and if necessary to take the supporting measures. For high extent of linking of medicament with proteins of plasma should not expect considerable strengthening of clearance of an atorvastatin by means of a hemodialysis.

Atorvastatin in general is well had by

.

treat undesirable reactions: thorax pain, face edema, fever, asthenia, muscle tension of a neck, weakness, photosensitization, generalized hypostases, indisposition, pyrexia, peripheral hypostases.

Interaction

Risk of development of a myopathy during treatment by statines increases in case of simultaneous use of derivatives of fibroyevy acid, lipidomodifikatsiyny doses of Niacinum, cyclosporine or powerful CYP inhibitors 3A4 (for example a klaritromitsina, inhibitors of HIV protease and an itrakonazol).

Grapefruit juice. Contains one or more components which inhibit CYP 3A4 and can increase concentration of an atorvastatin in blood plasma, especially at excess consumption of grapefruit juice (more than 1.2 liters a day).

Atorvastatin and his metabolites are OATP1B1 conveyor substrates. OATP1B1 inhibitors (for example cyclosporine) can increase bioavailability of an atorvastatin. The AUC value of an atorvastatin considerably increased at simultaneous use of an atorvastatin in a dose of 10 mg and cyclosporine in a dose of 5.2 mg/kg/days in comparison with use only of an atorvastatin. It is necessary to avoid simultaneous use of an atorvastatin and cyclosporine.

to Store

in original packing at a temperature not above 25 °C.

to Store

out of children's reach.

Expiration date - 2 years.