Amlodipin-Zdorovye of the tab. of 10 mg No. 30

Pharmacological properties

Amlodipin (3-ethyl-5-methyl ether (±)-2-[(aminometoks) - methyl]-4 (au chlorophenyls)-1.4-dihydro-6-methyls-3.5-pyridine dicarboxylic acids) — the dihydropyridinic antagonist of calcium ions (blocker of slow sa2+-channels). blocks a transmembrane stream of ions sa2 + mainly in cells of unstriated muscles of vessels and also cardiomyocytes. shows vazodilatiruyushchy, antihypertensive, anti-anginal, spasmolytic effects. the mechanism of antihypertensive action is caused by the direct weakening impact on unstriated muscles of vessels. thanks to the slow beginning of action and the prolonged effect does not cause the profound arterial hypotension, providing at single dose in day clinically significant smooth decrease hell and its control for 24 h

Amlodipin has anti-anginal effect due to expansion of peripheral arterioles and reduction of an afterload by heart, expansions of coronary vessels in not changed and ischemic zones of a myocardium. Reduces degree of a hypertrophy of a myocardium of a left ventricle. Slows down aggregation of thrombocytes. Increases glomerular filtration, slightly raises a natriuresis and a diuresis. Unlike dihydropyridinic antagonists of calcium of the first generation, amlodipin practically does not increase the level of catecholamines in blood plasma and does not stimulate a reninangiotenzinovy system.

it is Quickly soaked up after intake. The maximum concentration in blood plasma is reached in 6–12 h. The absolute bioavailability is 64–80%. Amlodipin biotransformirutsya in a liver with formation of inactive metabolites. Elimination half-life makes about 35 h. It is excreted with urine as in not changed look (10%), and in the form of metabolites (60%).

Indication

Ag, an ischemic heart disease — stable and vasospastic stenocardia (stenocardia printsmetat).

by

. the adult at ag and stenocardias appoint in an initial dose 5 mg of 1 times a day irrespective of meal. if necessary in 7–8 days the dose is raised to maximum — 10 mg/days the maximum therapeutic effect develop during 8 weeks

Contraindication

Hypersensitivity to an amlodipin, arterial hypotension.

Side effects

it is Usually well transferred; as side effects most often arise hypostases of shins, a headache, arterial hypotension, drowsiness, heartbeat, a dermahemia of the person, dizziness, nausea, an abdominal pain, is rare — skin allergic reactions, a hyperplasia of gums; at prolonged use — paresthesias and extremity pain.

Special instructions

At patients from the liver broken by function the elimination half-life of medicament increases that demands care at selection of a daily dose. safety of use of an amlodipin during pregnancy and feeding by a breast is not established therefore prescribing of medicament is possible only if the expected therapeutic effect for the pregnant woman or mother exceeds potential risk for a fruit or the baby.

Interaction

Amlodipin is characterized by lack of interaction with the medicines which are the most widely applied in clinical practice, including Cimetidinum, npvp, rifampicin, etc. at ag, the ischemic heart disease can be applied in a combination with blockers α- and β-adrenoceptors, inhibitors apf, nitrates, diuretics.

Overdose

Considerable overdose can lead hell, tachycardias to an excessive peripheral vazodilatation, the significant and long decrease. emergence of these symptoms demands medicament withdrawal; the patient is given horizontal position with the raised lower extremities. gastric lavage by a suspension of activated carbon, maintenance of function of a cardiovascular system with continuous monitoring of indicators of cardiac performance, lungs, otsk and a diuresis, in/in administration of plasma substitutes, calcium of a gluconate, dopamine, Phenylephrinum is shown. the hemodialysis is inefficient.

Storage conditions

B the dry, protected from light place at a temperature up to 25 °C.